Ethyl orthoformate → 7-(2-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

HRID 465122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 465122
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[CH:15](OCC)(OCC)OCC>>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:7]1[CH:6]=[CH:5][N:4]2[CH:15]=[N:2][N:1]=[C:3]2[CH:8]=1

Komponenten

3

Edukt 2

HCID 31214Ethyl orthoformateHCID 135337172'-Hydrazino-2,4'-bipyridine

Produkt 1

HCID 135337087-(2-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

Versuchsvorschrift

A mixture of 2.0 g of 2'-hydrazino-2,4'-bipyridine and 50 ml of triethyl orthoformate was heated on a steam bath for 18 hours then chilled and filtered. The crystals were dissolved in methylene chloride, treated with activated carbon, filtered and the filtrate concentrated. Chilling and filtration gave 1.5 g of the desired product as cream colored crystals, mp 144-°145° C.

Aufarbeitung

  1. temperaturewas heated on a steam bath for 18 hours
  2. temperaturethen chilled
  3. filtrationfiltered
  4. dissolutionThe crystals were dissolved in methylene chloride
  5. additiontreated with activated carbon
  6. filtrationfiltered
  7. concentrationthe filtrate concentrated
  8. temperatureChilling
  9. filtrationfiltration

Quellen und Nachweise

ORD-Eintrag
ord-1ff8877b5ac34ea2b3950340a906c49d
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04550166

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