Triethylamine → 2-(3-Phenoxybenzoyl)-3-dimethylaminoacrylonitrile

HRID 465274

Reaktionsgleichung

Reaktionsgleichung von HRID 465274
[O:1]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](Cl)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][N:18]([CH3:23])[CH:19]=[CH:20][C:21]#[N:22].C(N(CC)CC)C>O1CCOCC1>[O:1]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([C:20](=[CH:19][N:18]([CH3:23])[CH3:17])[C:21]#[N:22])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 974973-(Dimethylamino)prop-2-enenitrileHCID 27603413-Phenoxybenzoyl chloride

Produkt 1

HCID 540996322-(3-Phenoxybenzoyl)-3-dimethylaminoacrylonitrileAusbeute 36,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 3-phenoxybenzoyl chloride (6.9 g), 3-dimethylaminoacrylonitrile (2 g) and triethylamine (4 g) in dry dioxan (50 ml) was refluxed for 6 hours under a nitrogen atmosphere. After standing at room temperature overnight, the dioxan was evaporated in vacuo and dichloromethane added to the residue. The extracts were washed with water, 2N NaOH, brine and finally dried over MgSO4. After filtration and evaporation of the dichloromethane, the residue was purified on a silica gel column using 5% methanol-dichloromethane as eluant to give the title compound (2.2 g, 36%) as a white solid of m.p. 80°-82° C. (identical to that described in Example 46).

Aufarbeitung

  1. temperaturewas refluxed for 6 hours under a nitrogen atmosphere
  2. customthe dioxan was evaporated in vacuo and dichloromethane
  3. additionadded to the residue
  4. washThe extracts were washed with water, 2N NaOH, brine
  5. dry with materialfinally dried over MgSO4
  6. filtrationAfter filtration and evaporation of the dichloromethane
  7. customthe residue was purified on a silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-30ba1b7a3a6a4330b33d69566dcace07
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05152825

Verknüpfte Notizen

Wird geladen…