Hexane → Pentadecanoic Acid

HRID 465294

Reaktionsgleichung

Reaktionsgleichung von HRID 465294
[C:1]([O-])(=O)[CH2:2][C:3]([CH2:8][C:9]([O-:11])=[O:10])(C([O-])=O)O.[Cl-].[Cl-].[Ca+2].[CH3:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>OCC(CO)O>[C:9]([OH:11])(=[O:10])[CH2:8][CH2:3][CH2:2][CH2:1][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:1][CH2:2][CH2:3][CH3:8]

Komponenten

5

Edukt 3

HCID 8058HexaneHCID 31348CitrateHCID 5284359Calcium Chloride

Produkt 1

HCID 13849Pentadecanoic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 753GlycerolLösungsmittel

Versuchsvorschrift

Lipase (Lipase D10 manufactured by Amano Pharmaceutical Co., Ltd.) (60 mg) was dispersed in 15 ml of glycerol containing 8% v/v of 20 mM citrate buffer (pH 5.5) and 100 mM CaCl2 to form a lower layer, a solution of 375 mg of n-pentadecanoic acid in 50 ml of n-hexane (concentration 7.5 mg/ml) was provided thereon as the upper layer, and the two layers were stirred at 40° C. to carry out an esterification reaction at the interface between the two layers. The crystallizing bottle was maintained at 4° C. to obtain pentadecanoic acid monoglyceride. As a result, it was confirmed that pentadecanoic acid of 95% purity was synthesized.

Aufarbeitung

  1. customto form a lower layer

Quellen und Nachweise

ORD-Eintrag
ord-88fd012df05546cf9f3ddb902b301382
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05153126

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