Triphenylphosphine → (4S)-4-acetylthio-2-pyrrolidone

HRID 465344Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 465344
[OH:1][C@H:2]1[CH2:6][NH:5][C:4](=O)[CH2:3]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O.[C:39](O)(=[S:41])[CH3:40]>O1CCCC1>[C:2]([C@@H:3]1[CH2:4][NH:5][C:39](=[S:41])[CH2:40]1)(=[O:1])[CH3:6]

Komponenten

6

Edukt 4

HCID 11776TriphenylphosphineHCID 185505(R)-(+)-4-Hydroxy-2-pyrrolidinoneHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 178418634HCID 178418634, Verbindung

Produkt 1

HCID 86746170(4S)-4-acetylthio-2-pyrrolidone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

(4R)-4-Hydroxy-2-pyrrolidone (4.5 g) is suspended in tetrahydrofuran (300 ml), and thereto is added triphenylphosphine (23.4 g). After stirring the mixture for 10 minutes, diethyl azodicarboxylate (14 ml) is added dropwise to the mixture below -10° C., and the mixture is stirred at the same temperature for 10 minutes. Thioacetic acid (6.3 ml) is added dropwise to the reaction mixture below -10° C., and the mixture is stirred at the same temperature for 2 hours, and the solvent is evaporated under reduced pressure. The residue is crystallized from diisopropyl ether, and the precipitate is removed by filtration. The filtrate is concentrated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent, chloroform:ethanol=98:2) to give (4S)-4-acetylthio-2-pyrrolidone (3.8 g) as an oil.

Aufarbeitung

  1. stirringthe mixture is stirred at the same temperature for 10 minutes
  2. stirringthe mixture is stirred at the same temperature for 2 hours
  3. customthe solvent is evaporated under reduced pressure
  4. customThe residue is crystallized from diisopropyl ether
  5. customthe precipitate is removed by filtration
  6. concentrationThe filtrate is concentrated under reduced pressure
  7. customthe residue is purified by silica gel column chromatography (eluent, chloroform:ethanol=98:2)

Quellen und Nachweise

ORD-Eintrag
ord-8f4df708ec3c4f5cb4e12793f79d9828
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05153187

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