tert-Butanol → N-boc-4-chlorobenzenesulfonamide

HRID 465621

Reaktionsgleichung

Reaktionsgleichung von HRID 465621
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:14]([OH:18])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:12]([NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:9])=[O:10])=[O:13])([CH3:17])([CH3:16])[CH3:15]

Komponenten

3

Edukt 2

HCID 6386tert-ButanolHCID 1385874-Chlorobenzenesulfonyl isocyanate

Produkt 1

HCID 14796817N-boc-4-chlorobenzenesulfonamide

Versuchsvorschrift

The commercially available p-chlorophenylsulfonyl isocyanate (15.0 g, 58.6 mmol) is added dropwise to t-butanol (90 ml) and the mixture is allowed to stir at room temperature for 60 hours. The solvent is evaporated and the white solid is recrystallized from hexane and ethylacetate to obtain N-t-butoxycarbonyl-p-chlorophenylsulfonamide, m.p. 98°-99° C.

Aufarbeitung

  1. customThe solvent is evaporated
  2. customthe white solid is recrystallized from hexane and ethylacetate

Quellen und Nachweise

ORD-Eintrag
ord-c6fefe3fbe4c4b8ba246ce545c3a9649
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05153214

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