1-Ethynyl-4-methoxybenzene → 4-Methoxy-4'-(1-propynyl)tolan

HRID 465891Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 465891
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[CH:10])=[CH:5][CH:4]=1.[C:11]([C:14]1[CH:19]=[CH:18][C:17](I)=[CH:16][CH:15]=1)#[C:12][CH3:13]>C(NCC)C.[Cu](I)I>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][C:17]2[CH:18]=[CH:19][C:14]([C:11]#[C:12][CH3:13])=[CH:15][CH:16]=2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 2510201-Ethynyl-4-methoxybenzeneHCID 121767134-(1-Propynyl)iodobenzene

Produkt 1

HCID 598753514-Methoxy-4'-(1-propynyl)tolan

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 83717Copper iodideKatalysatorHCID 8021DiethylamineLösungsmittel

Versuchsvorschrift

4-Methoxyphenyl acetylene (2.65 g, 0.02 mol) and 4-(1-propynyl)iodobenzene (5.0 g, 0.02 mol) were dissolved in diethylamine (20 ml), and then added copper iodide (0.06 g) and dichlorobistriphenylphosphinepalladium dichloride (0.21 g) were added. The resulting mixture was subjected to reaction and purification operations in the same manners as in Example 1, to obtain the objective 4-methoxy-4'-(1-propynyl)tolan (No. 297) (1.35 g).

Aufarbeitung

  1. customThe resulting mixture was subjected to reaction and purification operations in the same manners as in Example 1

Quellen und Nachweise

ORD-Eintrag
ord-24a7db5658fb4840aea215ec309a8e30
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05154851

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