Triphenylphosphine dibromide → HCID 14971319, Verbindung

HRID 466173Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 466173
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH2:10][C:9]([CH2:12]O)=[CH:8][C:7]=2[CH:14]=1.[Br:15]P(Br)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH2:10][C:9]([CH2:12][Br:15])=[CH:8][C:7]=2[CH:14]=1

Komponenten

4

Edukt 2

HCID 70579Triphenylphosphine dibromideHCID 13601222HCID 13601222, Verbindung

Produkt 1

HCID 14971319HCID 14971319, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

6-Methoxy-3-(hydroxymethyl)-2H-1-benzopyran (4.35 g, 22.6 mmol) is dissolved in 70 ml of dry acetonitrile and treated with dibromotriphenylphosphorane (9.56 g, 22.6 mmol). After 15 min, the mixture is evaporated in vacuo. The residue is triturated with 100 ml of an ether/hexane mixture (1:1). The solid is removed by filtration (medium frit) and washed with several 50 ml portions of the ether/hexane mixture. The organic extracts are combined and evaporated to give 6-methoxy-3-(bromomethyl)-2H-1-benzopyran which is used without any further purification.

Aufarbeitung

  1. customthe mixture is evaporated in vacuo
  2. customThe residue is triturated with 100 ml of an ether/hexane mixture (1:1)
  3. customThe solid is removed by filtration (medium frit)
  4. washwashed with several 50 ml portions of the ether/hexane mixture
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d98e93658c5549a4a6365e494319f82a
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05155130

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