4-Bromophenol → 3-(4-bromophenoxy)-6-(1H-imidazol-1-yl)pyridazine

HRID 466552Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 466552
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[CH:6][CH:7]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1.C(=O)([O-])[O-].[Na+].[Na+]>CC(=O)C>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:2]2[N:3]=[N:4][C:5]([N:8]3[CH:12]=[CH:11][N:10]=[CH:9]3)=[CH:6][CH:7]=2)=[CH:16][CH:15]=1

Komponenten

5

Edukt 3

HCID 78084-BromophenolHCID 10340Sodium CarbonateHCID 27709033-Chloro-6-(1H-imidazol-1-yl)pyridazine

Produkt 1

HCID 151247883-(4-bromophenoxy)-6-(1H-imidazol-1-yl)pyridazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 4.5 parts of 3-chloro-6-(1H-imidazol-1-yl)pyridazine, 3.2 parts of 4-bromophenol, 4.2 parts of sodium carbonate and 80 parts of 2-propanone was stirred and refluxed over weekend. The reaction mixture was evaporated and the residue was taken up in water and 2,2'-oxybispropane. The layers were separated. The organic phase was dried, filtered and evaporated. The residue was crystallized from 2-propanol, yielding 3.5 parts of 3-(4-bromophenoxy)-6-(1H-imidazol-1-yl)pyridazine; mp. 168.4° C. (compound 6).

Aufarbeitung

  1. temperaturerefluxed over weekend
  2. customThe reaction mixture was evaporated
  3. customThe layers were separated
  4. customThe organic phase was dried
  5. filtrationfiltered
  6. customevaporated
  7. customThe residue was crystallized from 2-propanol

Quellen und Nachweise

ORD-Eintrag
ord-be7365baf3b8402dba7023bf35b465df
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05157035

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