Aluminum(III) Chloride → 2,3-Dichloro-4-hydroxy-N-n-butylaniline

HRID 466592

Reaktionsgleichung

Reaktionsgleichung von HRID 466592
[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([O:14]C)[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8].[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C(Cl)Cl>[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([OH:14])[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

4

Edukt 2

HCID 6451240Aluminum(III) ChlorideHCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

Produkt 1

HCID 198144102,3-Dichloro-4-hydroxy-N-n-butylaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 65911,1,2,2-TetrachloroethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 2,3-dichloro-4-methoxy-N-n-butylaniline (8.5 g) in 1,1,2,2-tetrachloroethane (80 ml) is added anhydrous aluminium chloride (8.5 g), and the mixture is refluxed for about 40 hours. The resulting mixture is poured into ice/water (about 500 ml), and the precipitated material is extracted twice with methylene chloride. The combined extracts are dried and evaporated in vacuo to give the title compound as a heavy oil.

Aufarbeitung

  1. temperaturethe mixture is refluxed for about 40 hours
  2. extractionthe precipitated material is extracted twice with methylene chloride
  3. customThe combined extracts are dried
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5d40f84d6c4f4309bd42f9714c203110
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05157039

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