Propargyl bromide → HCID 15065591, Verbindung

HRID 466754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 466754
[CH2:1](Br)[C:2]#[CH:3].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH2:10])[CH3:6].[CH2:14]1[CH2:18]OC[CH2:15]1>>[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][N:10]([CH2:18][C:14]#[CH:15])[CH2:1][C:2]#[CH:3])[CH3:6].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH:10][CH2:1][C:2]#[CH:3])[CH3:6]

Komponenten

5

Edukt 3

HCID 7842Propargyl bromideHCID 8028TetrahydrofuranHCID 695242,2-Diethoxyethylamine

Produkt 2

HCID 15065591HCID 15065591, VerbindungHCID 15065592HCID 15065592, Verbindung

Versuchsvorschrift

Propargyl bromide (14.7 g of 80% solution in toluene, 0.1 mol) was added to a stirred solution of aminoacetaldehyde diethyl acetal (13.3 g, 0.1 mol) in THF (200 mL). After 2 h the THF was removed and the residual oil was partitioned between ether and sodium hydroxide solution. Evaporation of the ether gave an oil which was chromatographed on silica gel to give 4.7 g of 2,2-diethoxy-N,N-bis-(2-propynyl)ethylamine and 8.1 g of 2,2-diethoxy-N-(2-propynyl)ethylamine.

Aufarbeitung

  1. customAfter 2 h the THF was removed
  2. customthe residual oil was partitioned between ether and sodium hydroxide solution
  3. customEvaporation of the ether
  4. customgave an oil which
  5. customwas chromatographed on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-0698c25eb20042a9b73206f28b9ad3e5
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05157124

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