2-Amino-4-Nitrophenol → 2-(Chloromethyl)-5-nitro-1,3-benzoxazole

HRID 467086

Reaktionsgleichung

Reaktionsgleichung von HRID 467086
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].Cl.[Cl:13][CH2:14][C:15](=N)OCC>C(O)C>[Cl:13][CH2:14][C:15]1[O:11][C:3]2[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=2[N:1]=1

Komponenten

4

Edukt 2

HCID 36133892-Amino-4-NitrophenolHCID 12470659Ethyl 2-chloroethanecarboximidate hydrochloride

Produkt 1

HCID 27641892-(Chloromethyl)-5-nitro-1,3-benzoxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Amino-4-nitrophenol (10 g, 65 mmole) and ethyl chloroacetimidate hydrochloride (15.4 g, 97.5 mmole) were heated at reflux temperature in ethanol (100 ml) for 18 hours. The solvent was then removed by evaporation in vacuo and the residue recrystallised from ethanol to give the title compound, yield 9.0 g, m.p. 216°-217°.

Aufarbeitung

  1. customThe solvent was then removed by evaporation in vacuo
  2. customthe residue recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-0c7cdef324e84958856a1348304f2bf5
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05158964

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