Methylamine → 2-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine

HRID 467442

Reaktionsgleichung

Reaktionsgleichung von HRID 467442
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8][CH2:9][C:10]2[CH:23]=[CH:22][C:13]([CH2:14][NH:15]C(=O)C(F)(F)F)=[CH:12][CH:11]=2)[N:3]=1.CN>CO>[NH2:15][CH2:14][C:13]1[CH:12]=[CH:11][C:10]([CH2:9][O:8][C:4]2[N:3]=[C:2]([NH2:1])[CH:7]=[CH:6][N:5]=2)=[CH:23][CH:22]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 86657016N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

Produkt 1

HCID 584459102-((4-(Aminomethyl)benzyl)oxy)pyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

150 mg (0.46 mmol) of N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide (1) is dissolved in 2 mL methanol and treated with 5 mL methylamine (33% in ethanol). The reaction mixture is stirred at room temperature over night and all volatiles are removed in vacuo. The product is used without further purification in the next step. ESI-MS m/z 231 [M+H]+.

Aufarbeitung

  1. customall volatiles are removed in vacuo
  2. customThe product is used without further purification in the next step

Quellen und Nachweise

ORD-Eintrag
ord-68d246155c0e4a528a24dd8480f2a2ec
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623627B2

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