Oxolan-3-amine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(tetrahydro-furan-3-ylcarbamoyl)-pyridin-3-yl]-amide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Oxolan-3-amine	HCID 3365553	—
Edukt	3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid	HCID 70098928	—
Produkt	6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(tetrahydro-furan-3-ylcarbamoyl)-pyridin-3-yl]-amide	HCID 58548271	96%

Reaktionsschritte

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 3-aminotetrahydro-furan, providing the title compound as yellow solid (96%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08623866B2
Quelldatensatz	uspto-grants-2014_01
ORD ID	ord-a77e728767834f17a18b819d27297762
Quellennotiz	uspto-grants-2014_01