2-Propanol, 1-amino-2-methyl- → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-hydroxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Propanol, 1-amino-2-methyl-	HCID 95102	—
Edukt	3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid	HCID 70098928	—
Produkt	6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-hydroxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide	HCID 58548161	74%

Reaktionsschritte

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 1-amino-2-methylpropan-2-ol, providing the title compound as yellow solid (74%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08623866B2
Quelldatensatz	uspto-grants-2014_01
ORD ID	ord-710c86833df94f7da0e38e7f9b6d63f3
Quellennotiz	uspto-grants-2014_01