3-Methoxy-2,2-dimethylpropan-1-amine--hydrogen chloride (1/1) → HCID 58548267, Verbindung

HRID 467733

Reaktionsgleichung

Reaktionsgleichung von HRID 467733
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[CH:21]=[N:20][CH:19]=[CH:18][C:14]=3[C:15](O)=[O:16])=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.Cl.[CH3:30][O:31][CH2:32][C:33]([CH3:37])([CH3:36])[CH2:34][NH2:35]>>[CH3:30][O:31][CH2:32][C:33]([CH3:37])([CH3:36])[CH2:34][NH:35][C:15]([C:14]1[CH:18]=[CH:19][N:20]=[CH:21][C:13]=1[NH:12][C:10]([C:8]1[C:7]([NH:22][C:23]2[CH:24]=[N:25][CH:26]=[N:27][CH:28]=2)=[N:6][CH:5]=[C:4]([CH:1]2[CH2:2][CH2:3]2)[N:9]=1)=[O:11])=[O:16]

Komponenten

3

Edukt 2

HCID 467821573-Methoxy-2,2-dimethylpropan-1-amine--hydrogen chloride (1/1)HCID 700989283-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid

Produkt 1

HCID 58548267HCID 58548267, VerbindungAusbeute 54 %

Versuchsvorschrift

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 3-methoxy-2,2-dimethylpropan-1-amine hydrochloride, the title compound as yellow solid (54%).

Quellen und Nachweise

ORD-Eintrag
ord-f3a1684ca14344f1ba0805ddb71b29c9
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623866B2

Verknüpfte Notizen

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