Dimethylamine → 2-Amino-6-methoxy-N,N-dimethyl-benzamide

HRID 467759Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 467759
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:3]=1[C:4](O)=[O:5].[CH3:13][NH:14][CH3:15]>>[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:3]=1[C:4]([N:14]([CH3:15])[CH3:13])=[O:5]

Komponenten

3

Edukt 2

HCID 674DimethylamineHCID 27353572-Amino-6-methoxybenzoic Acid

Produkt 1

HCID 700967842-Amino-6-methoxy-N,N-dimethyl-benzamide

Versuchsvorschrift

The product was obtained starting from 2-amino-6-methoxybenzoic acid (100 mg, 0.6 mmol) and dimethylamine (2M in THF, 420 μl, 0.84 mmol) according to the method described in example 64, step 6 after extraction with ethyl acetate and purification by silica gel chromatography using an amine phase and a heptane/ethyl acetate gradient as colorless oil (26 mg, 22%).

Aufarbeitung

  1. customThe product was obtained
  2. extractionafter extraction
  3. customwith ethyl acetate and purification by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-08c9af29497343df93bdc717b171c076
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623866B2

Notizen zur Reaktion

Wird geladen…