(S)-(+)-Tetrahydrofurfurylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (1-methyl-5-{[(S)-1-(tetrahydro-furan-2-yl)methyl]-carbamoyl}-1H-pyrazol-4-yl)-amide

HRID 467775

Reaktionsgleichung

Reaktionsgleichung von HRID 467775
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[CH:17]=[N:16][N:15]([CH3:18])[C:14]=3[C:19]([OH:21])=O)=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[O:29]1[CH2:33][CH2:32][CH2:31][C@H:30]1[CH2:34][NH2:35]>>[CH3:18][N:15]1[C:14]([C:19](=[O:21])[NH:35][CH2:34][C@@H:30]2[CH2:31][CH2:32][CH2:33][O:29]2)=[C:13]([NH:12][C:10]([C:8]2[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=[C:4]([CH:1]3[CH2:3][CH2:2]3)[N:9]=2)=[O:11])[CH:17]=[N:16]1

Komponenten

3

Edukt 2

HCID 641530(S)-(+)-TetrahydrofurfurylamineHCID 700980734-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid

Produkt 1

HCID 547594566-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (1-methyl-5-{[(S)-1-(tetrahydro-furan-2-yl)methyl]-carbamoyl}-1H-pyrazol-4-yl)-amide

Versuchsvorschrift

The product was obtained starting from 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid (30 mg, 79 μmol; example 236, step 3) and (S)-(tetrahydrofuran-2-yl)methanamine (15 μl, 142 μmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (31 mg, 84%).

Aufarbeitung

  1. customThe product was obtained
  2. customafter purification by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-753820d183d44bf39d4b5c27e80502b5
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623866B2

Verknüpfte Notizen

Wird geladen…