1-Methylazetidin-3-amine dihydrochloride → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [1-methyl-5-(1-methyl-azetidin-3-ylcarbamoyl)-1H-pyrazol-4-yl]-amide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-Methylazetidin-3-amine dihydrochloride	HCID 44784901	—
Edukt	4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid	HCID 70098073	—
Produkt	6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [1-methyl-5-(1-methyl-azetidin-3-ylcarbamoyl)-1H-pyrazol-4-yl]-amide	HCID 54760944	—

Reaktionsschritte

The product was obtained starting from 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid (30 mg, 79 μmol; example 236, step 3) and 1-methylazetidin-3-amine dihydrochloride (16 mg, 100 μmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (11 mg, 31%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08623866B2
Quelldatensatz	uspto-grants-2014_01
ORD ID	ord-62c52ecae7a44be19a3ad926a7b21654
Quellennotiz	uspto-grants-2014_01