N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide → N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide

HRID 467963Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 467963
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]([F:30])([F:29])[F:28])[CH:21]=2)[C:8]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]3[CH:18]=2)=[O:9])[CH2:3][CH2:2]1>[C].[Pd].CO>[O:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]([F:28])([F:29])[F:30])[CH:21]=2)[C:8]([C:10]2[N:11]=[C:12]3[CH2:17][CH2:16][CH2:15][CH2:14][N:13]3[CH:18]=2)=[O:9])[CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 58049370N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide

Produkt 1

HCID 46916730N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamideAusbeute 95,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-(tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide (50 mg), 10% palladium-carbon (50 mg) and methanol (15 mL) was stirred in a nitrogen atmosphere for 2 hours at room temperature. The insoluble matter was filtered off and methanol was distilled off under reduced pressure to give the titled compound (48 mg).

Aufarbeitung

  1. filtrationThe insoluble matter was filtered off
  2. distillationmethanol was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d15a8106b1404230a679aa89ae608dfc
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623898B2

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