1,1'-Carbonyldiimidazole → HCID 59625974, Verbindung

HRID 468179Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 468179
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[C:20](N1C=CN=C1)(N1C=CN=C1)=[O:21]>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[NH:1][C:20]2=[O:21])=[CH:14][CH:15]=1

Komponenten

4

Edukt 2

HCID 682631,1'-CarbonyldiimidazoleHCID 59625705HCID 59625705, Verbindung

Produkt 1

HCID 59625974HCID 59625974, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of 60d (0.20 g, 0.826 mmol) and 1,1′-carbonyldiimidazole (0.535 g, 3.3 mmol) in DMF (8 mL) was heated at 90° C. for 2 h. The solvent was removed and the residue was triturated with water (15 mL). The resulting precipitate was collected by filtration and washed several times with water. The crude product 60i was used in the next reaction without further purification. MS m/z (M+H+) 287.1.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe residue was triturated with water (15 mL)
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed several times with water
  5. customThe crude product 60i was used in the next reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-fce9c37bc6cb438d9f05cbaa5259d84a
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623858B2

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