Piperidine → HCID 178501989, Verbindung

HRID 46823

Reaktionsgleichung

Reaktionsgleichung von HRID 46823
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(Cl)Cl>[N:19]1([C:2]2[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 178501976HCID 178501976, Verbindung

Produkt 1

HCID 178501989HCID 178501989, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A suspension of 7.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 35 ml. of methylene chloride is treated with 14.5 ml. of piperidine and the mixture is stirred at room temperature under an argon atmosphere for 18 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 202° C. (decomposition).

Aufarbeitung

  1. additionA suspension of 7.5 g
  2. customThe white precipitate formed
  3. filtrationis filtered off
  4. customrecrystallized from a mixture of methylene chloride and methanol, there

Quellen und Nachweise

ORD-Eintrag
ord-cb980e29b6014349a7dfd3002a3011e4
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04175190

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