3-((4-Chloro-2-nitrophenyl)amino)propan-1-ol → 3-((2-Amino-4-chlorophenyl)amino)propan-1-ol

HRID 46857Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 46857
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][CH2:10][CH2:11][OH:12])=[C:4]([N+:13]([O-])=O)[CH:3]=1.[H][H]>[Ni].C(O)C>[NH2:13][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[NH:8][CH2:9][CH2:10][CH2:11][OH:12]

Komponenten

5

Edukt 2

HCID 6039763-((4-Chloro-2-nitrophenyl)amino)propan-1-olHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 30173573-((2-Amino-4-chlorophenyl)amino)propan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 34.6 parts of 3-[(4-chloro-2-nitrophenyl)amino]-1-propanol and 320 parts of ethanol is hydrogenated at normal pressure and at room temperature with 8 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated, yielding 30 parts of 3-[(2-amino-4-chlorophenyl)amino]-1-propanol as an oily residue.

Aufarbeitung

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-0bb03012e0f74914bdd16c73f4774abe
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04175129

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