HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,1'-Carbonyldiimidazole → 4-methoxy-N,2,6-trimethyl-N-[(4-{[4-(2-pyridin-4-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Edukt | 1-[2-(4-Pyridinyl)ethyl]piperazine | HCID 558685 | — |
| Edukt | 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid | HCID 58393097 | — |
| Lösungsmittel | 1,2-Dichloroethane | HCID 11 | — |
| Produkt | 4-methoxy-N,2,6-trimethyl-N-[(4-{[4-(2-pyridin-4-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide | HCID 58393315 | — |
Reaktionsschritte
The title compound was prepared according to general procedure AA using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (63 mg, 0.18 mmol), CDI (58 mg, 0.36 mmol) and 1-[2-(pyridin-4-yl)ethyl]piperazine (57 mg, 0.30 mmol) in DCE (4.5 mL). The crude product was purified using Ambersep and PL-MIA resins, then using prep method A.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08623859B2 |
| Quelldatensatz | uspto-grants-2014_01 |
| ORD ID | ord-9acf8c69bcc94a6fa68e800f138f8ff0 |
| Quellennotiz | uspto-grants-2014_01 |