1-(1-Methyl-4-piperidinyl)piperazine → Ammonia

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(1-Methyl-4-piperidinyl)piperazine	HCID 566324	—
Edukt	Trimethylaluminum	HCID 16682925	—
Edukt	ethyl 5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate	HCID 58393201	—
Lösungsmittel	1,2-Dichloroethane	HCID 11	—
Produkt	Ammonia	HCID 222	—
Produkt	N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide	HCID 58393376	—

Reaktionsschritte

The title compound was prepared according to general procedure AT using ethyl 5-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate (30 mg, 0.07 mmol), 1-(1-methylpiperidin-4-yl)piperazine (26 mg, 0.14 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08623859B2
Quelldatensatz	uspto-grants-2014_01
ORD ID	ord-79758d6df2224fe7b3180851d14d23a5
Quellennotiz	uspto-grants-2014_01