HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(3-Pyrrolidinopropyl)Piperazine → Ammonia
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(3-Pyrrolidinopropyl)Piperazine | HCID 2737252 | — |
| Edukt | Trimethylaluminum | HCID 16682925 | — |
| Edukt | ethyl 5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate | HCID 58393201 | — |
| Lösungsmittel | 1,2-Dichloroethane | HCID 11 | — |
| Produkt | Ammonia | HCID 222 | — |
| Produkt | N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide | HCID 46175283 | — |
Reaktionsschritte
The title compound was prepared according to general procedure AT using ethyl 5-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate (30 mg, 0.07 mmol), 1-[3-(pyrrolidin-1-yl)propyl]piperazine (31 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08623859B2 |
| Quelldatensatz | uspto-grants-2014_01 |
| ORD ID | ord-ec1cecb01d1f434e9eead81ef7b69f0a |
| Quellennotiz | uspto-grants-2014_01 |