Aluminum(III) Chloride → 6-(5-bromo-pyridin-3-carbonyl)-4-methyl-3H-benzoxazol-2-one

HRID 469326Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 469326
Cl.[Br:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:11]=1)[C:8](Cl)=[O:9].[CH3:12][C:13]1[C:18]2[NH:19][C:20](=[O:22])[O:21][C:17]=2[CH:16]=[CH:15][CH:14]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[Br:2][C:3]1[CH:11]=[C:7]([C:8]([C:15]2[CH:14]=[C:13]([CH3:12])[C:18]3[NH:19][C:20](=[O:22])[O:21][C:17]=3[CH:16]=2)=[O:9])[CH:6]=[N:5][CH:4]=1

Komponenten

4

Edukt 3

HCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-oneHCID 189717365-Bromo-nicotinic acid chloride hydrochloride

Produkt 1

HCID 581811166-(5-bromo-pyridin-3-carbonyl)-4-methyl-3H-benzoxazol-2-one

Versuchsvorschrift

2.57 g (10.0 mmol) 5-bromo-nicotinic acid chloride hydrochloride, 1.49 g (10.0 mmol) 4-methyl-3H-benzoxazol-2-one and 5.33 g (40.0 mmol) aluminium trichloride were heated to 125° C. with stirring for 1.5 h. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered, washed with water and dried i. vac.

Aufarbeitung

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried i

Quellen und Nachweise

ORD-Eintrag
ord-708df34646e244ee8b57dd9f0e41748c
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629137B2

Notizen zur Reaktion

Wird geladen…