3-Bromo-4-fluorobenzoyl chloride → 6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one

HRID 469333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 469333
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](Cl)=[O:6].[CH3:12][C:13]1[C:18]2[NH:19][C:20](=[O:22])[O:21][C:17]=2[CH:16]=[CH:15][CH:14]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([C:15]1[CH:14]=[C:13]([CH3:12])[C:18]2[NH:19][C:20](=[O:22])[O:21][C:17]=2[CH:16]=1)=[O:6]

Komponenten

4

Edukt 3

HCID 695983-Bromo-4-fluorobenzoyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-one

Produkt 1

HCID 581811656-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one

Versuchsvorschrift

2.23 g (9.40 mmol) 3-bromo-4-fluoro-benzoic acid chloride, 1.40 g (9.40 mmol) 4-methyl-3H-benzoxazol-2-one and 5.01 g (37.60 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered and washed with water. Then the precipitate was triturated with MeOH, suction filtered, washed with MeOH and dried i. vac.

Aufarbeitung

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customThen the precipitate was triturated with MeOH, suction
  5. filtrationfiltered
  6. washwashed with MeOH
  7. customdried i

Quellen und Nachweise

ORD-Eintrag
ord-f0500187676c41158cfad604f0265059
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629137B2

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