Thionyl Chloride → 4-Cyano-3-fluorobenzoyl chloride

HRID 469341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 469341
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[F:12])#[N:2].S(Cl)([Cl:15])=O>>[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:15])=[O:8])=[CH:5][C:4]=1[F:12])#[N:2]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 27784684-Cyano-3-fluorobenzoic acid

Produkt 1

HCID 199567394-Cyano-3-fluorobenzoyl chloride

Versuchsvorschrift

0.66 g (4.0 mmol) 4-cyano-3-fluoro-benzoic acid were mixed with 10 mL thionyl chloride and boiled for 2 h. The mixture was evaporated to dryness and coevaporated twice with toluene. The residue was reacted further as the crude product.

Aufarbeitung

  1. customThe mixture was evaporated to dryness
  2. customThe residue was reacted further as the crude product

Quellen und Nachweise

ORD-Eintrag
ord-5d904c35d39c4e24855c8b7d93a46084
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629137B2

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