Aluminum(III) Chloride → 2-Fluoro-4-(4-methyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-benzonitrile

HRID 469342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 469342
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][C:4]=1[F:12])#[N:2].[CH3:13][C:14]1[C:19]2[NH:20][C:21](=[O:23])[O:22][C:18]=2[CH:17]=[CH:16][CH:15]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[F:12][C:4]1[CH:5]=[C:6]([C:7]([C:16]2[CH:15]=[C:14]([CH3:13])[C:19]3[NH:20][C:21](=[O:23])[O:22][C:18]=3[CH:17]=2)=[O:8])[CH:10]=[CH:11][C:3]=1[C:1]#[N:2]

Komponenten

4

Edukt 3

HCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-oneHCID 199567394-Cyano-3-fluorobenzoyl chloride

Produkt 1

HCID 581811882-Fluoro-4-(4-methyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-benzonitrile

Versuchsvorschrift

0.73 g (4.0 mmol) 4-cyano-3-fluoro-benzoic acid chloride, 0.60 g (4.0 mmol) 4-methyl-3H-benzoxazol-2-one and 2.1 g (16 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was combined with ice water. The precipitate formed was suction filtered, washed with water and dried i. vac.

Aufarbeitung

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried i

Quellen und Nachweise

ORD-Eintrag
ord-844e169c07544f8e87ce02a2ab47f45d
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629137B2

Notizen zur Reaktion

Wird geladen…