Methyl 3-amino-2-thiophenecarboxylate → HCID 58557000, Verbindung

HRID 469451Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 469451
C([C:3](Br)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=[O:5])C.[NH2:14][C:15]1[CH:19]=[CH:18][S:17][C:16]=1[C:20]([O:22][CH3:23])=[O:21]>C(#N)C>[CH3:23][O:22][C:20]([C:16]1[S:17][CH:18]=[CH:19][C:15]=1[NH:14][CH:3]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[C:4]([OH:6])=[O:5])=[O:21]

Komponenten

4

Edukt 2

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 19431595Ethyl 2-bromo-2-phenylacetic acid

Produkt 1

HCID 58557000HCID 58557000, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of ethyl 2-bromo-2-phenylacetic acid (600 mg, 2.79 mmol) and methyl 3-aminothiophene-2-carboxylate (438 mg, 2.79 mmol) in acetonitrile (20 ml) was heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile was evaporated to dryness and the resulting residue was used in the next step without any further purification.

Aufarbeitung

  1. customAcetonitrile was evaporated to dryness
  2. customthe resulting residue was used in the next step without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-2852a2337e8d4caaa243ffaee22e39b6
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629160B2

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