2-(3,5-Dimethylphenyl)acetic acid → N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(3,5-dimethylphenyl)acetamide

HRID 469598

Reaktionsgleichung

Reaktionsgleichung von HRID 469598
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH3:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29](O)=[O:30])[CH:24]=[C:25]([CH3:27])[CH:26]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:23]3[CH:22]=[C:21]([CH3:20])[CH:26]=[C:25]([CH3:27])[CH:24]=3)[N:11]=2)=[CH:13][CH:14]=1

Komponenten

3

Edukt 2

HCID 47494952-(3,5-Dimethylphenyl)acetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Produkt 1

HCID 53239111N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(3,5-dimethylphenyl)acetamide

Versuchsvorschrift

The product of Example 86A and 2-(3,5-dimethylphenyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.41-8.43 (m, 1H), 7.93-8.04 (m, 2H), 7.72-7.74 (m, 1H), 7.59-7.69 (m, 4H), 6.98-6.99 (bs, 2H), 6.90-6.91 (bs, 1H), 3.60 (s, 2H), 2.26 (s, 6H); MS (ESI−) M/Z 416 (M−H)−.

Quellen und Nachweise

ORD-Eintrag
ord-299861c7b00c499e8853254b35253e10
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629143B2

Verknüpfte Notizen

Wird geladen…