2-Fluoroaniline → 4-Bromo-2-fluoroaniline

HRID 47007

Reaktionsgleichung

Reaktionsgleichung von HRID 47007
[Br:1]N1C(=O)CCC1=O.[F:9][C:10]1[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12]>C(Cl)Cl>[Br:1][C:15]1[CH:14]=[CH:13][C:11]([NH2:12])=[C:10]([F:9])[CH:16]=1

Komponenten

4

Edukt 2

HCID 95842-FluoroanilineHCID 67184N-bromobutanimide

Produkt 1

HCID 1230504-Bromo-2-fluoroaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

160 Parts of solid N-bromosuccinimide were added in portions over a 2 hour period to a solution of 100 parts of 2-fluoroaniline in 400 parts of methylene chloride cooled to 0°. After stirring for 20 minutes, the dark red mixture was washed four times; 200 parts of cold water were used for each washing. The red organic phase was dried with anhydrous sodium sulfate and evaporated at 300 mm.Hg to yield 164 parts of brown, oily 4-bromo-2-fluoroaniline, nD25 : 1.5885.

Aufarbeitung

  1. temperaturecooled to 0°
  2. washthe dark red mixture was washed four times
  3. dry with materialThe red organic phase was dried with anhydrous sodium sulfate
  4. customevaporated at 300 mm.Hg

Quellen und Nachweise

ORD-Eintrag
ord-637cb1ab1673407aa14706e6cc2e10fc
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04175948

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