Methanol → Methyl 3,4-dimethoxycinnamate

HRID 470618

Reaktionsgleichung

Reaktionsgleichung von HRID 470618
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][C:13]([OH:15])=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:16]O>S(=O)(=O)(O)O>[CH3:16][O:14][C:13](=[O:15])[CH:12]=[CH:11][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 168483',4'-Dimethoxycinnamic acid

Produkt 1

HCID 94307Methyl 3,4-dimethoxycinnamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

3-(3,4-Dimethoxy-phenyl)-acrylic acid (compound of Example 2 (Step 1); 1.0 g, 4.8 mmol) was dissolved in methanol (10 mL) in the presence of catalytic amount of sulfuric acid. The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was cooled at 5° C. and quenched with saturated sodium carbonate solution (2 mL). The solid obtained was filtered and dried.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled at 5° C.
  2. customquenched with saturated sodium carbonate solution (2 mL)
  3. customThe solid obtained
  4. filtrationwas filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0389e983858e4fde970403772b1e0438
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629277B2

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