Hydrochloric Acid → 1-Benzylpiperidine-4-acetonitrile

To a solution of benzylpiperidin-4-ylideneacetonitrile (compound of Example 26; 1 g, 4.7 mmol) in methanol (50 mL), magnesium turnings (4.58 g, 188.3 mmol) was added at 0° C. The reaction mixture was stirred at 5° C. to 10° C. for 4 h. The magnesium salts were dissolved by addition of concentrated hydrochloric acid, and the mixture was basified with 10N sodium hydroxide solution. The precipitate was filtered and extracted with ethyl acetate (2×20 mL). The combined organic layers were washed with water (2×15 mL) followed by brine (10 mL). The organic phase obtained was dried over anhydrous sodium sulphate and evaporated to afford the title compound.

1. filtrationThe precipitate was filtered
2. extractionextracted with ethyl acetate (2×20 mL)
3. washThe combined organic layers were washed with water (2×15 mL)
4. customThe organic phase obtained
5. dry with materialwas dried over anhydrous sodium sulphate
6. customevaporated

ORD-Eintrag

ord-4aa1d79e9e7d4f9f8508f261759f8239

Quelldatensatz

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08629277B2