(S)-4-aminobutane-1,2-diol → (4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-1'-[(1R,2S)-2-hydroxy-1,2-diphenylethyl]-4,4-dimethyl-2''-oxo-1'',2''-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxamide

Reaktionsgleichung

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C@@:6]3([C:19]4([CH2:24][CH2:23][C:22]([CH3:26])([CH3:25])[CH2:21][CH2:20]4)[N:18]4[C@@H:13]([C:14](=[O:39])[O:15][C@@H:16]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)[C@H:17]4[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[C@@H:12]3[C:40]3[CH:45]=[CH:44][CH:43]=[C:42]([Cl:46])[C:41]=3[F:47])[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[NH2:48][CH2:49][CH2:50][C@H:51]([OH:54])[CH2:52][OH:53]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3([C@@H:12]([C:40]4[CH:45]=[CH:44][CH:43]=[C:42]([Cl:46])[C:41]=4[F:47])[C@H:13]([C:14]([NH:48][CH2:49][CH2:50][C@H:51]([OH:54])[CH2:52][OH:53])=[O:39])[N:18]([C@H:17]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[C@@H:16]([OH:15])[C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=4)[C:19]43[CH2:20][CH2:21][C:22]([CH3:26])([CH3:25])[CH2:23][CH2:24]4)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1