1-(2-Furoyl)piperazine → 5,6-Dimethoxy-3(4-furoyl piperazino)methylene oxindole

HRID 47070

Reaktionsgleichung

Reaktionsgleichung von HRID 47070
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15]O.[O:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)=[O:23]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15][N:27]1[CH2:28][CH2:29][N:24]([C:22]([C:18]2[O:17][CH:21]=[CH:20][CH:19]=2)=[O:23])[CH2:25][CH2:26]1

Komponenten

3

Edukt 2

HCID 5502061-(2-Furoyl)piperazineHCID 178486553HCID 178486553, Verbindung

Produkt 1

HCID 706018865,6-Dimethoxy-3(4-furoyl piperazino)methylene oxindole

Versuchsvorschrift

3.0 g. of 5,6-Dimethoxy-3-hydroxymethylene oxindole was reacted with 4.0 g. N-furoyl piperazine as described in Example 2 except that 0.10 g. toluene sulfone acid was added as a catalyst. Yield 3.46 g. of product, m.p. 158°-160° C.

Quellen und Nachweise

ORD-Eintrag
ord-480b826da78b4e26b491233566a86978
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04176191

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