5-Ethylthiophene-3-carboxylic acid → (5-Ethylthiophen-3-yl)(9-(3-(2-hydroxyethyl)benzyl)-2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

HRID 471286Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 471286
[CH3:1][C:2]1([CH3:23])[CH2:7][NH:6][CH2:5][C:4]2([CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:15]=[C:16]([CH2:20][CH2:21][OH:22])[CH:17]=[CH:18][CH:19]=3)[CH2:9][CH2:8]2)[O:3]1.[CH2:24]([C:26]1[S:30][CH:29]=[C:28]([C:31](O)=[O:32])[CH:27]=1)[CH3:25]>>[CH2:24]([C:26]1[S:30][CH:29]=[C:28]([C:31]([N:6]2[CH2:5][C:4]3([CH2:12][CH2:11][N:10]([CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][CH2:21][OH:22])[CH:15]=4)[CH2:9][CH2:8]3)[O:3][C:2]([CH3:23])([CH3:1])[CH2:7]2)=[O:32])[CH:27]=1)[CH3:25]

Komponenten

3

Edukt 2

HCID 35615485-Ethylthiophene-3-carboxylic acidHCID 579890912-(3-((2,2-Dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)ethanol

Produkt 1

HCID 57988969(5-Ethylthiophen-3-yl)(9-(3-(2-hydroxyethyl)benzyl)-2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

Versuchsvorschrift

The subtitled compound was prepared using a similar method to that described in Example 271 step (f) using 2-(3-((2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)ethanol (0.2 g) (Example 271, step e) and 5-ethylthiophene-3-carboxylic acid. Yield 0.22 g.

Quellen und Nachweise

ORD-Eintrag
ord-0897fd7b3d094660bdd5d0c662c91e07
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629271B2

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