Phosphorus oxychloride → 4-Chloro-6-ethyl-5-iodopyrimidine

HRID 471389

Reaktionsgleichung

Reaktionsgleichung von HRID 471389
O[C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:13]>>[Cl:13][C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 1784377446-ethyl-5-iodo-1H-pyrimidin-4-one

Produkt 1

HCID 109784874-Chloro-6-ethyl-5-iodopyrimidine

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additionthe residue is poured
  3. custominto crushed ice
  4. filtrationThe precipitated solid is collected by filtration
  5. washwashed with water
  6. customAfter drying

Quellen und Nachweise

ORD-Eintrag
ord-6cd1afec87c74639a86a29cbb8cdcfc3
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08633183B2

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