HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 5-Ethynyl-6-methylpyridin-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 6-Methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine | HCID 59255232 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 5-Ethynyl-6-methylpyridin-2-amine | HCID 55285938 | — |
Reaktionsschritte
The title compound is synthesized according to general procedure GP3 starting from 4.3 g (21.0 mmol) 6-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 1.5 g (10.5 mmol) K2CO3 in 30 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 3.6 g.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08633183B2 |
| Quelldatensatz | uspto-grants-2014_01 |
| ORD ID | ord-58497208515045d296a66d57ed8c6e9d |
| Quellennotiz | uspto-grants-2014_01 |