Hydrochloric Acid → methyl (S)-3-amino-2-(4-ethylpiperazin-1-yl)propanoate trihydrochloride

HRID 472140

Reaktionsgleichung

C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH3:22])[CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:23]>CO>[ClH:23].[ClH:23].[ClH:23].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH2:20]1)[C:11]([O:13][CH3:14])=[O:12]

Komponenten

Reaktionsbedingungen

Temperatur: 40 °C

Versuchsvorschrift

2.5 g (7.9 mmol) of methyl (S)-3-tert-butoxycarbonylamino-2-(4-ethylpiperazin-1-yl)propanoate are placed in 20 ml of methanol and 10 ml of isopropanolic hydrochloric acid having a concentration of 5-6N. The reaction medium is heated at 40° C. for 3 h and then evaporated to dryness. The residue is taken up in 50 ml of ethanol, stirred for 1 h at ambient temperature and then filtered. 1.4 g (54%) of methyl (S)-3-amino-2-(4-ethylpiperazin-1-yl)propanoate trihydrochloride are obtained in the form of a beige solid.

Aufarbeitung

customevaporated to dryness
filtrationfiltered

Quellen und Nachweise

ORD-Eintrag: ord-63f3e406aff542a7856cd3ad3cca4248
Quelldatensatz: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08633196B2

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