Methylamine → 6-Bromo-8-isopropyl-4-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

HRID 472199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 472199
[Br:1][C:2]1[C:15](=[O:16])[N:14]([CH:17]([CH3:19])[CH3:18])[C:5]2[N:6]=[C:7](S(C)=O)[N:8]=[C:9]([CH3:10])[C:4]=2[CH:3]=1.[CH3:20][NH2:21]>O1CCOCC1>[Br:1][C:2]1[C:15](=[O:16])[N:14]([CH:17]([CH3:19])[CH3:18])[C:5]2[N:6]=[C:7]([NH:21][CH3:20])[N:8]=[C:9]([CH3:10])[C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 592589926-bromo-8-isopropyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Produkt 1

HCID 592589706-Bromo-8-isopropyl-4-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-oneAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a stirred solution of 6-bromo-8-isopropyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one (175 mg, 0.508 mmol) in 1,4-dioxane (2.5 mL) was added methyl amine (0.80 mL, 2.0 M in THF, 1.6 mmol). The mixture was sealed and heated at 110° C. microwave for 15 min. The solvent was evaporated and the crude product was washed with EtOAc/Hexane to give the title compound (158 mg, 76%).

Aufarbeitung

  1. customThe mixture was sealed
  2. customThe solvent was evaporated
  3. washthe crude product was washed with EtOAc/Hexane

Quellen und Nachweise

ORD-Eintrag
ord-eb6031ecda784d24aeef3cd3de8f3309
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08633204B2

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