Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro- → HCID 136397840, Verbindung

HRID 47267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47267
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14].[NH:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[C@H:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=2)=[CH:19][CH:18]=1)[NH2:16]>C(O)C>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:16][NH:15][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[C@H:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=3)=[CH:19][CH:18]=2)=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14]

Komponenten

4

Edukt 2

HCID 96959Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro-HCID 69529174(R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Produkt 1

HCID 136397840HCID 136397840, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 4-hydroxy-3-methoxy-2-nitro-benzaldehyde (1.6 g) in ethanol (15 ml) was added to a suspension of (R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one (1.75 g) in ethanol (20 ml) and the resulting mixture refluxed for two hours. The resulting crystals were filtered at room temperature and washed with ethanol. Yield 2.37 g. HPLC: purity 99.4%, optical purity 99.8%.

Aufarbeitung

  1. temperaturethe resulting mixture refluxed for two hours
  2. filtrationThe resulting crystals were filtered at room temperature
  3. washwashed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-b9d0cf976a794ddeb6ba1b5f4e6d51f5
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699868B2

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