Triphenyl phosphite → HCID 178517777, Verbindung

Temperatur

150 °C

To 2,2-difluoro-2-(5-fluoropyridin-2-yl)acetic acid from Example 33 step A (863 mg, 4.52 mmol) and 2-amino-3-(trifluoromethoxy)benzoic acid (1 g, 4.52 mmol) in pyridine (15 mL) was added triphenyl phosphite (1.3 mL, 4.97 mmol) and the mixture was heated in a microwave synthesizer at 150° C. for 10 min. The mixture was cooled to rt and then ethyl 3-aminopropanoate hydrochloride (763 mg, 4.97 mmol) was added and the mixture heated in a microwave synthesizer at 190° C. for 4 min. The crude mixture was concentrated under reduced pressure. THF (30 mL) was added followed by sodium ethoxide (21% in EtOH, 5 mL) and the mixture stirred at 60° C. for 0.5 h. The cooled mixture was concentrated under reduced pressure, dissolved in water and the pH adjusted to <4 by addition of 4 N HCl. The precipitate was collected by filtration, washed with water, and allowed to dry to afford 2-(difluoro(5-fluoropyridin-2-yl)methyl)-8-(trifluoromethoxy)quinazolin-4-ol (1.31 g, 77%) as a crude tan solid which was used in the next step without further purification.

1. temperatureThe mixture was cooled to rt
2. temperaturethe mixture heated in a microwave synthesizer at 190° C. for 4 min
3. concentrationThe crude mixture was concentrated under reduced pressure
4. additionTHF (30 mL) was added
5. concentrationThe cooled mixture was concentrated under reduced pressure
6. dissolutiondissolved in water
7. additionthe pH adjusted to <4 by addition of 4 N HCl
8. filtrationThe precipitate was collected by filtration
9. washwashed with water
10. customto dry

ORD-Eintrag

ord-50c95cc9623f4c5da9dd7948f0c04252

Quelldatensatz

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08633207B2