HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 47351Erstellt: 23. Oktober 2026
Propyl isocyanate → 4-[2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperazinyl]-2-oxoethyl]-N-propyl-1-piperidinecarboxamide
https://huagongshe.com/de/reaction/47351
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Propyl isocyanate | HCID 61033 | — |
| Edukt | 1-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-4-[(4-piperidinyl)acetyl]piperazine | HCID 10768220 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 4-[2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperazinyl]-2-oxoethyl]-N-propyl-1-piperidinecarboxamide | HCID 10769930 | 112,9% |
Reaktionsschritte
1-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-4-[(4-piperidinyl)acetyl]piperazine (Preparative Example 10) (490 mg, 0.8 mmoles) was dissolved in anhydrous dichloromethane (5 ml) and n-propyl isocyanate (322.1 mg, 3.2 mmoles) was added. The mixture was stirred under argon at 25° C. for 44 h. The solution was chromatographed on silica gel using 2% (10% concentrated NH4OH in methanol)dichloromethane as the eluant to give 544.8 mg of the title compound (Yield: 95%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US06699872B2 |
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| Quelldatensatz | uspto-grants-2004_03 |
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| ORD ID | ord-1951beaeb4f14e549384a1c72b7a7480 |
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| Quellennotiz | uspto-grants-2004_03 |
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