HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → 8-chloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | Cyclopentadiene | HCID 7612 | — |
| Edukt | 4-Chloroaniline | HCID 7812 | — |
| Edukt | 2-Ketobutyrate | HCID 3593277 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 8-chloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester | HCID 9965449 | 89% |
Reaktionsschritte
Compound 3 was prepared in a yield of 89% by the basic process from 5.0 mmol 4-chloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol cyclopentadiene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06699877B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-0a43b64858bc4a909c3d85b6456cc7da |
| Quellennotiz | uspto-grants-2004_03 |