Trifluoroacetic acid → 5,7-dichloro-4-(2,4-dimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47376Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47376
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[CH3:17][C:18]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:19]=1C=C.FC(F)(F)C(O)=O.[OH-].[Na+]>C(#N)C.C(O)C>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:4]2[C:3]=1[CH:11]([C:19]1[CH:22]=[CH:23][C:24]([CH3:26])=[CH:25][C:18]=1[CH3:17])[CH2:10][CH:12]([C:13]([OH:15])=[O:14])[NH:5]2

Komponenten

8

Edukt 5

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 14798Sodium HydroxideHCID 166942,4-DimethylstyreneHCID 35932772-Ketobutyrate

Produkt 1

HCID 99463775,7-dichloro-4-(2,4-dimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Compound 22 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 2,4-dimethylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

Quellen und Nachweise

ORD-Eintrag
ord-a0336ceea30a42ed8d5a3bc52c698fd4
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699877B2

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