Trifluoroacetic acid → 4-(3-bromophenyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47392

Reaktionsgleichung

Reaktionsgleichung von HRID 47392
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[Br:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)C=C.FC(F)(F)C(O)=O.[OH-].[Na+]>C(#N)C.C(O)C>[Br:17][C:18]1[CH:25]=[C:24]([CH:11]2[C:3]3[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=3[Cl:1])[NH:5][CH:12]([C:13]([OH:15])=[O:14])[CH2:10]2)[CH:23]=[CH:20][CH:19]=1

Komponenten

8

Edukt 5

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 14798Sodium HydroxideHCID 748703-BromostyreneHCID 35932772-Ketobutyrate

Produkt 1

HCID 101791474-(3-bromophenyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Compound 38 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 3-bromostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

Quellen und Nachweise

ORD-Eintrag
ord-761463aeb882489b81a0f6fa1ba80bbe
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699877B2

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