Trifluoroacetic acid → 4-(4-bromophenyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47394

Reaktionsgleichung

Reaktionsgleichung von HRID 47394
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[Br:17][C:18]1[CH:25]=[CH:24][C:21](C=C)=[CH:20][CH:19]=1.FC(F)(F)C(O)=O.[OH-].[Na+]>C(#N)C.C(O)C>[Br:17][C:18]1[CH:25]=[CH:24][C:21]([CH:11]2[C:3]3[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=3[Cl:1])[NH:5][CH:12]([C:13]([OH:15])=[O:14])[CH2:10]2)=[CH:20][CH:19]=1

Komponenten

8

Edukt 5

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 14798Sodium HydroxideHCID 162634-BromostyreneHCID 35932772-Ketobutyrate

Produkt 1

HCID 102010254-(4-bromophenyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Compound 40 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-bromostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

Quellen und Nachweise

ORD-Eintrag
ord-638a400385b2400ca3182ab90c300c27
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699877B2

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