Trifluoroacetic acid → 6-Chloro-4-(2,4,6-trimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

HRID 47403

Reaktionsgleichung

Reaktionsgleichung von HRID 47403
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH2:9]([C:11](=O)[C:12]([O-:14])=[O:13])[CH3:10].[CH3:16][C:17]1[CH:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[C:18]=1C=C.F[C:28](F)(F)[C:29](O)=O>C(#N)C>[CH2:28]([O:14][C:12]([CH:11]1[CH2:9][CH:10]([C:24]2[C:17]([CH3:16])=[CH:18][C:21]([CH3:26])=[CH:22][C:23]=2[CH3:25])[C:7]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:8]=2)[NH:6]1)=[O:13])[CH3:29]

Komponenten

6

Edukt 4

HCID 6422Trifluoroacetic acidHCID 78124-ChloroanilineHCID 130362,4,6-TrimethylstyreneHCID 35932772-Ketobutyrate

Produkt 1

HCID 101330026-Chloro-4-(2,4,6-trimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Compound 49 was prepared by the basic process from 5.0 mmol 4-chloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 2,4,6-trimethylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

Quellen und Nachweise

ORD-Eintrag
ord-d326ce09a18c49a4b5baf9d653371c92
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699877B2

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