C1(P([N:15]=[N+]=[N-])(C2C=CC=CC=2)=O)C=CC=CC=1.C(OC([C:23]1([C:31]2[CH:36]=[CH:35][N:34]=[C:33]([Br:37])[CH:32]=2)[CH2:28][O:27][C:26]([CH3:30])([CH3:29])[O:25][CH2:24]1)=O)C.C(N(CC)CC)C.C(OCC)(=O)C>C1(C)C=CC=CC=1.CCCCCC>[Br:37][C:33]1[CH:32]=[C:31]([C:23]2([NH2:15])[CH2:28][O:27][C:26]([CH3:30])([CH3:29])[O:25][CH2:24]2)[CH:36]=[CH:35][N:34]=1Dipheny phosphoryl azide (14.3 mL, 66.45 mmol) was added to a solution of 5-(2-bromo-pyridin-4-yl)-2,2-dimethyl-[1,3]dioxane-5-carboxylic acid ethyl ester (14.0 g, 44.3 mmol) and triethyl amine (17.24 ml, 133.0 mmol) in toluene (100 ml) at 0° C. The resultant reaction mixture was heated to 80° C. under constant stirring for 7 h. Reaction mixture was concentrated under reduced pressure to remove solvent completely. The residue obtained after concentration was dissolved in THF (100 ml) and cooled to 0° C. 2 N aq. NaOH solution was added drop wise and stirred for 30 min at rt. Reaction mixture was concentrated under reduced pressure to remove THF and the residue obtained was extracted with ethylacetate. Organic layer was washed with water, brine and dried over anhy. Na2SO4. Organic layer was concentrated under reduced pressure to obtain furnished brownish oily material which was solidified at low temperature (<10° C.). Yield=9.5 g (75%). TLC (50% ethyl acetate in hexane) Rf=0.15; LCMS: RtH7=0.083; [M+1]+=287.0 and 289.0.
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